As a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from the aspects of ototoxic drugs, aging, and acoustic trauma and discussed whether autophagy could serve as a potential measure in the protection of HCs.

中文翻译：

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自噬：毛细胞保护的新视野

作为一种普遍的感觉障碍，听力损失是全球关注的主要问题。自噬是一种常见的细胞对压力的反应，它通过溶酶体途径降解细胞质废物。自噬不仅在维持细胞内稳态中发挥重要作用，而且还参与了许多疾病的发展和发病机制。在听觉系统中，一些研究揭示了自噬与听力保护之间的联系。在这篇综述中，我们旨在从耳毒性药物、衰老和听觉创伤等方面建立自噬与毛细胞 (HCs) 之间的相关性，并讨论自噬是否可以作为保护 HCs 的潜在措施。