Abstract:

Objectives: Population-level estimates of the median intracerebral hemorrhage (ICH) volume would allow for the evaluation of clinical trial external validity and determination of temporal trends. We previously reported the median ICH volume in 1988. However, differences in risk factor management, neuroimaging and demographics may have affected ICH volumes. The goal of this study was to determine the median volume of ICH within a population-based cross-sectional study, including whether it has changed over time.

Methods: The Genetic and Environmental Risk Factors for Hemorrhagic Stroke study was a population-based study of ICH among residents of the Greater Cincinnati/Northern Kentucky region from 2008 through 2012. The current study utilizes those data and compares with ICH cases from the same region in 1988. Initial CT images of the head were reviewed, and ICH volumes were calculated using consistent methodology.

Results: From 2008 through 2012, we identified 1117 cases of ICH. The median volume of ICH was 14.0 mL and was lower in black (11.6) than in white (15.5) patients. Median volumes of lobar and deep ICH were 28·8 mL and 9.8 mL, respectively. Median ICH volume changed significantly from 1988 to 2008-2012, with age-and-race adjusted volume decreasing from 18.3 mL to 13.76 mL (p=0.025).

Conclusions: Median volume of ICH was 13.76 mL, and this should be considered in clinical trial design. Median ICH volume has apparently decreased from 1988 to 2008-2012.

摘要：

目标：脑出血 (ICH) 体积中位数的人口水平估计将允许评估临床试验的外部有效性和确定时间趋势。我们之前在 1988 年报告了 ICH 体积的中位数。然而，风险因素管理、神经影像学和人口统计学方面的差异可能影响了 ICH 体积。本研究的目的是确定基于人群的横断面研究中 ICH 体积的中位数，包括它是否随时间发生变化。

方法：出血性中风的遗传和环境风险因素研究是一项基于人群的 ICH 研究，研究对象是 2008 年至 2012 年大辛辛那提/北肯塔基地区的居民。目前的研究利用这些数据并与来自同一地区的 ICH 病例进行比较1988 年。审查了头部的初始 CT 图像，并使用一致的方法计算了 ICH 体积。

结果：从 2008 年到 2012 年，我们确定了 1117 例 ICH。ICH 体积中位数为 14.0 mL，黑人患者 (11.6) 低于白人患者 (15.5)。脑叶和深 ICH 的中位数体积分别为 28·8 mL 和 9.8 mL。从 1988 年到 2008-2012 年，中位 ICH 体积发生了显着变化，年龄和种族调整后的体积从 18.3 mL 减少到 13.76 mL (p=0.025)。

结论：ICH 的中位体积为 13.76 mL，在临床试验设计中应考虑这一点。从 1988 年到 2008-2012 年，ICH 数量中位数明显下降。