An effi cient and unifi ed approach for the enantioselective synthesis of two important yet challenging classes of tricyclic chroman scaffolds by site-selective organocatalytic asymmetric cascade reactions of newly designed phenol-based trifunctional substrates bearing two reactive nucleophilic groups is descried. Unprecedentedly, the enantioselectivities of the present reaction can be switched by altering the remote nucleophilic groups of the substrates.

中文翻译：

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三环色满的对映发散合成：远程亲核基团在三功能底物的催化不对称级联反应中转换选择性

描述了通过新设计的带有两个反应性亲核基团的酚基三官能底物的位点选择性有机催化不对称级联反应对映选择性合成两种重要但具有挑战性的三环色满支架的有效和统一的方法。前所未有地，本反应的对映选择性可以通过改变底物的远程亲核基团来改变。