Abstract

Depression is associated with cognitive deficits and changes in the brain. Major depression is often associated with cognitive problems; however, there are only a few studies that have focused on the systematic use of cognitive remediation in depression. The objective of this study was to assess the effectiveness of computerized cognitive remediation in depressed patients with cognitive dysfunction. Patients (n = 20) with depression were randomly assigned to the active or control group. The active intervention (computerized cognitive remediation) comprised 12 sessions focused on the remediation of attention and executive functions through the CogniPlus software. All participants completed neuropsychological testing before and after the intervention. A mixed-design analysis of variance revealed a significant time × group interaction in the attention and planning task, on the Beck Depression Inventory and on the Shifting, Emotional Control and Initiating sub-scales of the Behavior Rating Inventory of Executive Function-Adult. The results showed that patients undergoing cognitive remediation improved in domains related to attention and executive functions and scored significantly lower on the Beck Depression Inventory. The findings provide some evidence that cognitive remediation could be an efficient approach to dealing with cognitive deficits in depression.

摘要

抑郁症与认知缺陷和大脑变化有关。重度抑郁症通常与认知问题有关；然而，只有少数研究侧重于在抑郁症中系统地使用认知矫正。本研究的目的是评估计算机化认知治疗对伴有认知功能障碍的抑郁症患者的有效性。患者（n = 20) 抑郁症患者被随机分配到活动组或对照组。主动干预（计算机化认知矫正）包括 12 节课，重点是通过 CogniPlus 软件矫正注意力和执行功能。所有参与者在干预前后都完成了神经心理学测试。混合设计方差分析显示，在注意力和计划任务、贝克抑郁量表和执行功能成人行为评定量表的转移、情绪控制和启动子量表中，时间×组间的相互作用显着。结果表明，接受认知矫正的患者在与注意力和执行功能相关的领域有所改善，并且在贝克抑郁量表上的得分显着降低。