The laboratory rat (Rattus norvegicus) has been used for a long time as the model of choice in several biomedical disciplines. In 2020, I made an inventory of rat genes that had been identified as underlying diseases or playing a key role in critical biological processes that are altered in diseases. Over 350 genes could be found, a significant number of which have similar effects in rat and humans (Szpirer in J Biomed Sci 27:84–155, 2020). However, a few rat disease genes were unintentionally overlooked; in addition, since this review was published, numerous rat genes were inactivated by targeted mutations, revealing their potential role in diseases. It thus seems appropriate to update these data, which is the aim of this paper.

实验室大鼠 ( Rattus norvegicus ) 长期以来一直被用作多个生物医学学科的首选模型。2020 年，我对已被确定为潜在疾病或在疾病中发生改变的关键生物过程中发挥关键作用的大鼠基因进行了清点。可以发现超过 350 个基因，其中相当一部分在大鼠和人类中具有相似的作用（Szpirer in J Biomed Sci 27:84–155, 2020）。然而，一些大鼠疾病基因被无意中忽视了。此外，自从这篇综述发表以来，许多大鼠基因被靶向突变灭活，揭示了它们在疾病中的潜在作用。因此，更新这些数据似乎是合适的，这是本文的目的。