Characterizing the functional mechanism of quality control marker (Q-marker) was of great importance in revealing the primary pharmacological mechanism of herbs or the other complex system, and drug-related metabolites always contribute to the pharmacological functions. Cortex Phellodendri was used as a core herb in the treatment of diabetes mellitus (DM). As a Q-marker of Cortex Phellodendri, the role of phellodendrine in DM was still unclear. Thus, the characterization of phellodendrine-related metabolites in vivo and the subsequent induced functional mechanism exerted great importance in elucidating the anti-DM mechanism of Cortex Phellodendri.

中文翻译：

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通过超高效液相色谱-耦合飞行时间质谱和网络药理学表征黄柏的代谢命运及其对糖尿病的潜在药理机制

表征质量控制标志物（Q-marker）的功能机制对于揭示草药或其他复杂系统的主要药理机制具有重要意义，而药物相关代谢物总是有助于药理功能。黄柏被用作治疗糖尿病 (DM) 的核心草药。作为黄柏的 Q 标记，黄柏在 DM 中的作用尚不清楚。因此，体内黄柏相关代谢物的表征和随后的诱导功能机制对于阐明黄柏的抗 DM 机制具有重要意义。