Abstract

Macrocyclic ligands offer an efficient means to modify metal complex geometry, to regulate its kinetics, electronic structure, and reactivity. Here, the kinetic studies of [M^IIL]Cl₂ tetraazamacrocyclic complexes (M = Ni and Cu, and L is dichloro-[2,4,9,13,15,20-hexamethyldibenzo-1,4,8,11-tetraazacyclotetra-decatetraene]) have been taken into the account. The kinetic data have indicated the greater inertness of the macrocyclic ligands towards Ni^II/Cu^II transition metals. This is attributed to the alteration in the coordination environment of metal octahedral to square planar conformation. The result is compatible with the solvating process of released metal ion and macrocyclic ligands. In addition, the biological activity of both the complexes against Gram +ve and Gram –ve bacteria has been carried out. The results indicate that the Cu^II complex can be served as a potential model for antimicrobial activity against the Gram +ve and Gram –ve bacteria.

中文翻译：

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镍（II）和铜（II）大环配合物的动力学和生物学研究

摘要

大环配体提供了一种有效的方法来改变金属配合物的几何形状，以调节其动力学、电子结构和反应性。在这里，[M ^II L]Cl ₂四氮杂大环配合物的动力学研究（M = Ni 和Cu，L 是二氯-[2,4,9,13,15,20-六甲基二苯并-1,4,8,11-四氮杂环四-十碳四烯]) 已被考虑在内。动力学数据表明大环配体对 Ni ^II / Cu ^{II 的}惰性更大过渡金属。这归因于金属八面体到方形平面构象的配位环境的改变。结果与释放的金属离子和大环配体的溶剂化过程相容。此外，还进行了复合物对革兰氏阳性菌和革兰氏阴性菌的生物活性。结果表明，Cu ^II复合物可以作为对革兰氏 + ve 和革兰 - ve 细菌的抗菌活性的潜在模型。