Abstract—Aqueous sols of hafnia modified with organic quantum dots, which exhibit pronounced luminescent properties, have been synthesized by hydrothermal treatment of amorphous hydrated hafnium dioxide in the presence of ammonium citrate. It has been shown that malignant human cells of the U-251, MCF-7, and MNNG/Hos lines take up the resulting nanoparticles to a significantly higher degree than human mesenchymal stem cells. Under X-ray radiation (15 Gy), the resulting nanoparticles exhibit radiosensitizing properties against malignant cells of the U-251 and MCF-7 lines, significantly reducing their viability. On the contrary, in relation to human osteosarcoma cells of the MNNG/Hos line, the radiosensitizing properties of the obtained material are much less pronounced.

摘要——在柠檬酸铵存在下，通过对无定形水合二氧化铪进行水热处理，合成了有机量子点改性的铪水溶胶，该溶胶具有显着的发光性能。已经表明，U-251、MCF-7 和 MNNG/Hos 系的恶性人类细胞比人类间充质干细胞吸收所得纳米颗粒的程度要高得多。在 X 射线辐射 (15 Gy) 下，所得纳米颗粒对 U-251 和 MCF-7 系的恶性细胞表现出放射增敏特性，显着降低了它们的生存能力。相反，对于 MNNG/Hos 系的人骨肉瘤细胞，所获得材料的放射增敏特性不那么明显。