In contrast to Darwinian evolution, which is founded on the material competition between organisms, cellular epigenetic evolution focuses on cell-cell communication of data from one stage of life to another-developmentally, phylogenetically, as injury-repair – ultimately governed by the First Principles of Physiology. By merging ontogeny and phylogeny, since both are based on cell-cell communication mediated by soluble growth factors and their receptors, evolution complies as one holistic, unified process. As such, the material aspects of the organism can be seen as ‘means’ instead of ‘ends’, begging the question as to just what the ‘ends’ of evolution are ? Once the superficial material aspect of lifeforms is eliminated, only the flow of energy is left, within and between generations. Contemporary biology and physics are at a critical phase, unable to reduce their problems to practice. A paradigm shift to evolution as energy flow is proposed as the solution.

与建立在生物体之间物质竞争基础上的达尔文进化论相比，细胞表观遗传进化侧重于数据从一个生命阶段到另一个阶段的细胞间通信——在发育上、系统发育上、作为损伤修复——最终受第一原理支配生理学。通过合并个体发育和系统发育，由于两者都基于由可溶性生长因子及其受体介导的细胞间通讯，因此进化作为一个整体、统一的过程进行。因此，有机体的物质方面可以被视为“手段”而不是“目的”，这就引出了一个问题，即进化的“目的”是什么？一旦生命形式的表面物质方面被消除，就只剩下能量的流动，在世代之内和世代之间。当代生物学和物理学正处于关键阶段，无法将他们的问题减少到实践中。作为解决方案，提出了向能量流进化的范式转变。