In this study, we have described a facile process for fabrication of multifunctional composite hydrogel, in which sodium alginate was subjected to cross-linking using Ca²⁺ derived from ZnO/CaCO₃/Ag composite nanospheres. The ZnO/CaCO₃/Ag composite nanospheres were prepared based on our previously reported AA-[Zn(OH)₄]^2- composite nanosphere reaction conducted with silver and calcium salt following hydrothermal method, that led to the disintegration and release of Ca²⁺ under acidic conditions for application as a cross-linking agentto catalyze reaction with sodium alginate. Ag nanoparticles were well-dispersed in the multifunctional composite hydrogel, exhibiting excellent antibacterial activity. Additionally, polydopamine (PDA) with photothermal effect was also added to obtain a multifunctional composite hydrogel, and this hydrogel showed photothermal conversion performance and facilitated the release of Ag⁺ to achieve the rapid antibacterial effect. Simultaneously, PDA NPs could scavenge free radicals and improve cell adhesion. All such features would promote wound healing. The potent antimicrobial activity of the prepared composite hydrogel was demonstrated in the mouse model of S. aureus infection, and biosafety of the hydrogel was confirmed by conducting histopathological examination in the mouse model. This type of multifunctional hydrogel wound dressing with photosensitive and antibacterial properties presents with broad applications and prospects in antibacterial treatment.

中文翻译：

---

具有良好分散的银纳米颗粒的热敏复合水凝胶的简便合成，用于卓越的抗菌感染。

在这项研究中，我们描述了一种制备多功能复合水凝胶的简便方法，其中使用源自 ZnO/ CaCO3 /Ag 复合纳米球的Ca ²⁺对海藻酸钠进行交联。基于我们之前报道的 AA-[Zn(OH)₄] ^2-复合纳米球反应制备了 ZnO/CaCO₃/Ag 复合纳米球，该反应通过水热法与银和钙盐进行反应，导致 Ca ²⁺的分解和释放在酸性条件下用作交联剂，催化与海藻酸钠反应。Ag纳米粒子在多功能复合水凝胶中分散良好，表现出优异的抗菌活性。此外，还加入了具有光热效应的聚多巴胺（PDA），得到了多功能复合水凝胶，该水凝胶具有光热转换性能，促进Ag ⁺的释放，达到快速抗菌效果。同时，PDA NPs 可以清除自由基并改善细胞粘附。所有这些特征都会促进伤口愈合。在金黄色葡萄球菌小鼠模型中证明了制备的复合水凝胶的有效抗菌活性通过在小鼠模型中进行组织病理学检查证实了水凝胶的感染和生物安全性。这种具有光敏和抗菌特性的多功能水凝胶伤口敷料在抗菌治疗中具有广泛的应用和前景。