Lidocaine-loaded nanoparticles are versatile nanomaterials that may be used in pain treatment due to their wound healing properties. The current study describes a wound dressing formulation focused on lidocaine-loaded dextran/ethylene glycol nanoparticles (an anesthetic drug). The lidocaine-loaded dextran/ethylene glycol membranes were fabricated using lidocaine solutions inside the dextran/ethylene glycol medium. The influence of various experimental conditions on dextran/ethylene glycol nanoparticle formations were examined. The sizes of dextran/ethylene glycol and lidocaine-loaded dextran/glycol nanoparticles were examined through the HR-SEM. Moreover, the efficacy antibacterial activity of dextran/glycol and lidocaine-loaded dextran/ethylene glycol nanoparticles was evaluated against the microorganisms grampositive and negative. Furthermore, we observed the In Vivo wound healing of wounds in skin using a mice model over a 16 days period. In this difference to the wounds of untreated mouse, quick healing was observed in the lidocaine-loaded dextran/glycol nanoparticles-treated wounds with fewer injury. These results specify that lidocaine-loaded dextran/ethylene glycol nanoparticles-based dressing material could be a ground-breaking nanomaterial having wound repair and implantations potential required for wound injury in pain management, which was proven using an animal model.

中文翻译：

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用于疼痛管理的利多卡因 (LCH) 包裹的葡聚糖 (DEX)/乙二醇 (GLY) 纳米颗粒递送的体内组织植入模型的体内组织植入模型。

负载利多卡因的纳米颗粒是多功能纳米材料，由于其伤口愈合特性，可用于疼痛治疗。目前的研究描述了一种伤口敷料配方，重点是负载利多卡因的葡聚糖/乙二醇纳米颗粒（一种麻醉药）。加载利多卡因的葡聚糖/乙二醇膜是使用葡聚糖/乙二醇介质内的利多卡因溶液制造的。检查了各种实验条件对葡聚糖/乙二醇纳米颗粒形成的影响。通过 HR-SEM 检查了葡聚糖/乙二醇和负载利多卡因的葡聚糖/乙二醇纳米颗粒的尺寸。此外，还评估了葡聚糖/乙二醇和负载利多卡因的葡聚糖/乙二醇纳米颗粒对革兰氏阳性和阴性微生物的抗菌活性。此外，使用小鼠模型在 16 天内进行皮肤伤口的体内伤口愈合。在与未经治疗的小鼠伤口的这种差异中，在负载利多卡因的葡聚糖/乙二醇纳米颗粒治疗的伤口中观察到快速愈合且损伤较少。这些结果表明，负载利多卡因的葡聚糖/乙二醇纳米颗粒基敷料材料可能是一种突破性的纳米材料，具有疼痛管理中伤口损伤所需的伤口修复和植入潜力，这一点已通过动物模型得到证实。