The bio-based platform chemicals 2,3-butanediol (BDO) and acetoin have various applications in chemical, cosmetics, food, agriculture, and pharmaceutical industries, whereas the derivatives of BDO could be used as fuel additives, polymer and synthetic rubber production. This review summarizes the novel technological developments in adapting genetic and metabolic engineering strategies for selection and construction of chassis strains for BDO and acetoin production. The valorization of renewable feedstocks and bioprocess development for the upstream and downstream stages of bio-based BDO and acetoin production are discussed. The techno-economic aspects evaluating the viability and industrial potential of bio-based BDO production are presented. The commercialization of bio-based BDO and acetoin production requires the utilization of crude renewable resources, the chassis strains with high fermentation production efficiencies and development of sustainable purification or conversion technologies.

生物基平台化学品 2,3-丁二醇 (BDO) 和乙偶姻在化工、化妆品、食品、农业和制药行业有多种应用，而 BDO 的衍生物可用作燃料添加剂、聚合物和合成橡胶生产。本综述总结了采用遗传和代谢工程策略选择和构建用于 BDO 和乙偶姻生产的底盘菌株的新技术发展。讨论了生物基 BDO 和乙偶姻生产的上游和下游阶段的可再生原料的价值和生物工艺开发。介绍了评估生物基 BDO 生产的可行性和工业潜力的技术经济方面。