To investigate the usefulness of quenching probe polymerase chain reaction (Q-probe PCR) for detection of macrolides-resistant Mycoplasma pneumoniae (MP), we retrospectively analyzed the clinical course of 21 children with MP infection. The rate of macrolides resistant MP was 66.7%. The duration of pyrexia after the initial antibiotics treatment was longer in patients with macrolides-resistant MP infection than in those with macrolides-sensitive MP infection. The duration of pyrexia after Q-probe PCR was not significantly different between patients with macrolides-resistant MP infection and those with macrolides-sensitive MP infection. These results suggest that antibiotic use based on Q-probe PCR will reduce duration of pyrexia. Q-probe PCR contributes to determine appropriate antibiotics and to improve the clinical course of MP infections.

探讨淬灭探针聚合酶链式反应（Q-probe PCR）对大环内酯类耐药肺炎支原体检测的有效性（MP），我们回顾性分析了21例MP感染儿童的临床病程。大环内酯类MP耐药率为66.7%。大环内酯类耐药 MP 感染患者初始抗生素治疗后发热的持续时间长于大环内酯类敏感 MP 感染患者。Q-probe PCR 后发热持续时间在大环内酯类耐药 MP 感染患者和大环内酯类敏感 MP 感染患者之间没有显着差异。这些结果表明基于 Q-probe PCR 的抗生素使用将减少发热的持续时间。Q-probe PCR 有助于确定合适的抗生素并改善 MP 感染的临床过程。