Poly-drug consumption contributes to fatal overdose in more than half of all poly-drug users. Analyzing decision-making networks may give insight into the motivations behind poly-drug use. We correlated average functional connectivity of the valuation system (VS), executive control system (ECS) and valuation-control complex (VCC) in a large population sample (n = 992) with drug use behaviour. VS connectivity is correlated with sedative use, ECS connectivity is separately correlated with hallucinogens and opiates. Network connectivity is also correlated with drug use via two-way interactions with other substances including alcohol and tobacco. These preliminary findings can contribute to our understanding of the common combinations of substance co-use and associated neural patterns.

超过一半的多种药物使用者因服用多种药物而导致致命的药物过量。分析决策网络可以深入了解多种药物使用背后的动机。我们将大量人口样本 (n = 992) 中的评估系统 (VS)、执行控制系统 (ECS) 和评估-控制复合体 (VCC) 的平均功能连通性与吸毒行为相关联。VS 连通性与镇静剂使用相关，ECS 连通性分别与致幻剂和阿片类药物相关。网络连接还通过与其他物质（包括酒精和烟草）的双向相互作用与药物使用相关联。这些初步发现有助于我们理解物质共同使用和相关神经模式的常见组合。