Severe acute respiratory syndrome coronavirus (SARS-COV-2) is the culprit of the Coronavirus Disease (COVID-19), which has infected approximately 173 million people and killed more than 3.73 million. At risk groups including diabetic and obese patients are more vulnerable to COVID-19-related complications and poor outcomes. Substantial evidence points to hypovitaminosis D as a risk factor for severe disease, the need for ICU, and mortality. 1,25(OH)D, a key regulator of calcium homeostasis, is believed to have various immune-regulatory roles including; promoting anti-inflammatory cytokines, down regulating pro-inflammatory cytokines, dampening entry and replication of SARS-COV-2, and the production of antimicrobial peptides. In addition, there are strong connections which suggest that dysregulated 1,25(OH)D levels play a mechanistic and pathophysiologic role in several disease processes that are shared with COVID-19 including: diabetes, obesity, acute respiratory distress syndrome (ARDS), cytokine storm, and even hypercoagulable states. With evidence continuing to grow for the case that low vitamin D status is a risk factor for COVID-19 disease and poor outcomes, there is a need now to address the public health efforts set in place to minimize infection, such as lock down orders, which may have inadvertently increased hypovitaminosis D in the general population and those already at risk (elderly, obese, and disabled). Moreover, there is a need to address the implications of this evidence and how we may apply the use of cheaply available supplementation, which has yet to overcome the near global concern of hypovitaminosis D. In our review, we exhaustively scope these shared pathophysiologic connections between COVID-19 and hypovitaminosis D.

严重急性呼吸系统综合症冠状病毒 (SARS-COV-2) 是冠状病毒病 (COVID-19) 的罪魁祸首，该病已感染约 1.73 亿人，并导致超过 373 万人死亡。包括糖尿病患者和肥胖患者在内的高危人群更容易受到 COVID-19 相关并发症和不良后果的影响。大量证据表明维生素 D 缺乏症是严重疾病、需要 ICU 和死亡率的危险因素。1,25(OH)D 是钙稳态的关键调节剂，被认为具有多种免疫调节作用，包括：促进抗炎细胞因子，下调促炎细胞因子，抑制 SARS-COV-2 的进入和复制，以及抗菌肽的产生。此外，有很强的联系表明失调 1，25(OH)D 水平在与 COVID-19 共有的几种疾病过程中发挥机制和病理生理作用，包括：糖尿病、肥胖、急性呼吸窘迫综合征 (ARDS)、细胞因子风暴，甚至高凝状态。随着越来越多的证据表明，低维生素 D 状态是 COVID-19 疾病和不良结果的一个危险因素，现在有必要解决为最大限度减少感染而采取的公共卫生措施，例如封锁令、这可能无意中增加了普通人群和已经处于危险中的人群（老年人、肥胖者和残疾人）的维生素 D 缺乏症。此外，有必要解决这一证据的含义以及我们如何应用廉价补充剂的使用，这尚未克服几乎全球对维生素 D 缺乏症的关注。在我们的评论中，