Recent advances in microfluidics and microfabrication technology enabled the emergence of a new microelectrode-dot-array (MEDA) architecture for microfluidic biochips. The MEDA-based design allows dynamic routing with variable-sized droplets. The cross contamination avoidance between droplets of different biomolecules subjected for analysis and detection on MEDA architecture poses a major design challenge for development of MEDA-based biochips. In this article, we propose a precise technique for droplet routing with minimal cross contamination for MEDA-based biochips. Here we first evaluate the probability of cross contamination between any two droplets within the 2-D MEDA layout. Thereby, we propose a routing scheme for functional droplets specifically targeted for intelligent cross-contamination avoidance. As evident from the experimental results, the proposed technique effectively reduces both intra and inter subproblem cross contaminations. Experiment results shows considerable improvements over contemporary works.

中文翻译：

---

基于 MEDA 的生物芯片中的液滴传输：智能避免交叉污染的增强技术


微流体和微加工技术的最新进展使得用于微流体生物芯片的新型微电极点阵列（MEDA）架构的出现。基于 MEDA 的设计允许使用可变尺寸的液滴进行动态路由。在 MEDA 架构上进行分析和检测的不同生物分子液滴之间的交叉污染避免对基于 MEDA 的生物芯片的开发提出了主要的设计挑战。在本文中，我们提出了一种针对基于 MEDA 的生物芯片以最小交叉污染的方式实现液滴路径的精确技术。在这里，我们首先评估 2-D MEDA 布局内任意两个液滴之间交叉污染的概率。因此，我们提出了一种专门针对智能避免交叉污染的功能液滴的路由方案。从实验结果可以看出，所提出的技术有效地减少了子问题内和子问题间的交叉污染。实验结果表明，与当代作品相比，有相当大的进步。