Objective

Depression occurs at least two times more often in rheumatoid arthritis (RA) patients than in controls, but little is known about the treatment of depression in RA. The primary objective of this study was to compare the 1 year period prevalence of antidepressant prescription in patients with RA versus controls.

Method

We included a retrospective inception cohort of 509 patients with incident RA and 2545 frequency-matched population controls ascertained from 1995 to 2002. The cohort was followed until 31 December 2017 and linked with nationwide Danish registers. From the Danish National Prescription Register, we obtained information on redeemed prescriptions of antidepressants (Anatomical Therapeutic Chemical code N06A).

Results

We did not demonstrate significant differences in the 1 year period prevalence ratios and the incidence rate ratios for either antidepressant prescription or the frequency of hospital admissions with depressive episode. The most frequent indication for antidepressant prescription in patients with RA was depression. Cox regression analyses showed no association between RA and antidepressant prescription.

Conclusion

We found no significant differences in the occurrence of antidepressant prescription in patients with RA versus matched controls. The main indication for antidepressant prescription in RA was depression.

中文翻译：

---

类风湿关节炎和对照组的抗抑郁药处方没有差异。来自基于人群的匹配初始队列的结果

客观的

类风湿性关节炎 (RA) 患者的抑郁症发生率至少是对照组的两倍，但对 RA 抑郁症的治疗知之甚少。本研究的主要目的是比较 RA 患者与对照组抗抑郁药处方的 1 年流行率。

方法

我们纳入了 1995 年至 2002 年确定的 509 名 RA 患者和 2545 名频率匹配的人群对照的回顾性初始队列。该队列随访至 2017 年 12 月 31 日，并与丹麦全国登记处相关联。从丹麦国家处方登记处，我们获得了有关抗抑郁药赎回处方的信息（解剖治疗化学代码 N06A）。

结果

我们没有证明抗抑郁药处方的 1 年患病率和发病率比或因抑郁发作住院的频率存在显着差异。RA 患者最常见的抗抑郁处方指征是抑郁症。Cox 回归分析显示 RA 和抗抑郁药处方之间没有关联。

结论

我们发现 RA 患者的抗抑郁药处方发生率与匹配对照无显着差异。RA 中抗抑郁药处方的主要适应症是抑郁症。