Excessive beta-band oscillations in the subthalamic nucleus are key neural features of Parkinson’s disease. Yet the distinctive contributions of beta low and high bands, their dependency on striatal dopamine, and their correlates with movement kinematics are unclear. Here, we show that the movement phases of the reach-to-grasp motor task are coded by the subthalamic bursting activity in a maximally-informative beta high range. A strong, three-fold correlation linked beta high range bursts, imbalanced inter-hemispheric striatal dopaminergic tone, and impaired inter-joint movement coordination. These results provide new insight into the neural correlates of motor control in parkinsonian patients, paving the way for more informative use of beta-band features for adaptive deep brain stimulation devices.

丘脑底核中过度的 β 波段振荡是帕金森病的关键神经特征。然而，beta 低频段和高频段的独特贡献、它们对纹状体多巴胺的依赖以及它们与运动运动学的相关性尚不清楚。在这里，我们展示了到达抓取运动任务的运动阶段是由下丘脑爆发活动在最大信息量的 beta 高范围内编码的。强烈的三重相关性将 β 高程爆发、不平衡的半球间纹状体多巴胺能基调和关节间运动协调性受损。这些结果为帕金森病患者运动控制的神经相关性提供了新的见解，为将 β 波段特征用于自适应深部脑刺激设备提供更多信息铺平了道路。