Preeclampsia is a global health problem and it is the main cause of maternal and perinatal morbidity and mortality. Breastfeeding has been reported to be associated with lower postpartum blood pressure in women with gestational hypertension. However, there is no published data on the role that breastfeeding might play in preventing preeclampsia. The aim of the current study was to investigate if breastfeeding was associated with preeclampsia in parous women. A case-control study was conducted in Saad Abualila Maternity Hospital in Khartoum, Sudan, from May to December 2019. The cases (n = 116) were parous women with preeclampsia. Two consecutive healthy pregnant women served as controls for each case (n = 232). The sociodemographic, medical, and obstetric histories were gathered using a questionnaire. Breastfeeding practices and duration were assessed. A total of 98 (84.5%) women with preeclampsia and 216 (93.1%) women in the control group had breastfed their previous children. The unadjusted odds ratio (OR) of preeclampsia (no breastfeeding vs breastfeeding) was 3.55, 95% confidence interval (CI) 1.64,7.70 and p value = 0.001 based on these numbers. After adjusting for age, parity, education level, occupation, history of preeclampsia, history of miscarriage, body mass index groups the adjusted OR was 3.19, 95% CI 1.49, 6.82 (p value = 0.006). Breastfeeding might reduce the risk for preeclampsia. Further larger studies are required.

中文翻译：

---

经产妇女母乳喂养与先兆子痫的关系：病例对照研究

先兆子痫是一个全球性的健康问题，它是孕产妇和围产期发病率和死亡率的主要原因。据报道，母乳喂养与妊娠期高血压妇女的产后血压降低有关。然而，没有关于母乳喂养可能在预防先兆子痫方面发挥作用的已发表数据。本研究的目的是调查母乳喂养是否与经产妇女的先兆子痫有关。2019 年 5 月至 12 月在苏丹喀土穆的 Saad Abualila 妇产医院进行了一项病例对照研究。 病例（n = 116）是患有先兆子痫的经产妇女。两名连续的健康孕妇作为每个病例的对照（n = 232）。使用问卷收集社会人口统计学、医学和产科病史。对母乳喂养的做法和持续时间进行了评估。共有 98 名 (84.5%) 子痫前期妇女和 216 名 (93.1%) 对照组妇女曾母乳喂养她们之前的孩子。基于这些数字，先兆子痫（未母乳喂养与母乳喂养）的未调整优势比 (OR) 为 3.55，95% 置信区间 (CI) 1.64、7.70 和 p 值 = 0.001。在调整年龄、产次、教育水平、职业、先兆子痫史、流产史、体重指数组后，调整后的 OR 为 3.19，95% CI 1.49，6.82（p 值 = 0.006）。母乳喂养可能会降低先兆子痫的风险。需要进一步更大规模的研究。基于这些数字，先兆子痫（未母乳喂养与母乳喂养）的未调整优势比 (OR) 为 3.55，95% 置信区间 (CI) 1.64、7.70 和 p 值 = 0.001。在调整年龄、产次、教育水平、职业、先兆子痫史、流产史、体重指数组后，调整后的 OR 为 3.19，95% CI 1.49，6.82（p 值 = 0.006）。母乳喂养可能会降低先兆子痫的风险。需要进一步更大规模的研究。基于这些数字，先兆子痫（未母乳喂养与母乳喂养）的未调整优势比 (OR) 为 3.55，95% 置信区间 (CI) 1.64、7.70 和 p 值 = 0.001。在调整年龄、产次、教育水平、职业、先兆子痫史、流产史、体重指数组后，调整后的 OR 为 3.19, 95% CI 1.49, 6.82 (p 值 = 0.006)。母乳喂养可能会降低先兆子痫的风险。需要进一步更大规模的研究。