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Detection of immunoglobulin response to COVID-19 vaccination using a novel rapid fingerstick assay
Clinical Immunology ( IF 4.5 ) Pub Date : 2021-06-29 , DOI: 10.1016/j.clim.2021.108791
Beth L Cobb 1 , Amr H Sawalha 2
Affiliation  

Coronavirus Disease 2019 (COVID-19) emerged as a global pandemic resulting in significant mortality and morbidity. COVID-19 vaccines have been shown to be highly effective in preventing COVID-19 infections and significantly reducing disease severity and mortality. We report on a novel COVID-19 antibody test using a unique platform to rapidly detect SARS-CoV-2 antibodies with a drop of fingerstick blood in a subject following COVID-19 vaccination. We show early detection of SARS-CoV-2 antibodies post vaccination and persistence of detectable antibodies for at least 6 months. Rapid point of care COVID-19 antibody tests might have a role in assessing the appearance and durability of immune response following COVID-19 vaccination.



中文翻译:

使用新型快速指尖检测法检测免疫球蛋白对 COVID-19 疫苗的反应

2019 年冠状病毒病 (COVID-19) 已成为全球大流行病,导致显着的死亡率和发病率。COVID-19 疫苗已被证明在预防 COVID-19 感染和显着降低疾病严重程度和死亡率方面非常有效。我们报告了一项新型 COVID-19 抗体测试,该测试使用独特的平台在 COVID-19 疫苗接种后通过受试者的指尖血滴快速检测 SARS-CoV-2 抗体。我们显示在接种疫苗后及早检测到 SARS-CoV-2 抗体,并且可检测抗体持续存在至少 6 个月。快速床旁 COVID-19 抗体检测可能在评估 COVID-19 疫苗接种后免疫反应的出现和持久性方面发挥作用。

更新日期:2021-06-29
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