OBJECTIVE People with Alzheimer's disease (AD) dementia have impaired sleep. However, the characteristics of sleep in the early stages of AD are not well known, and studies with the aid of biomarkers are lacking. We assessed the subjective sleep characteristics of non-demented older adults and compared their amyloid profiles. METHODS We enrolled 30 participants aged ≥ 60 years, with no dementia or major clinical and psychiatric diseases. They underwent [11C]PiB-PET-CT, neuropsychological evaluations, and completed two standardized sleep assessments (Pittsburgh Sleep Quality Inventory and Epworth Sleep Scale). RESULTS Comparative analysis of subjective sleep parameters across the two groups showed longer times in bed (p = 0.024) and reduced sleep efficiency (p = 0.05) in individuals with positive amyloid. No differences in other subjective sleep parameters were observed. We also found that people with multiple-domain mild cognitive impairment (MCI) had shorter self-reported total sleep times (p = 0.034) and worse overall sleep quality (p = 0.027) compared to those with single-domain MCI. CONCLUSIONS Older adults testing positive for amyloid had a longer time in bed and lower sleep efficiency, regardless of cognitive status. In parallel, individuals with multiple-domain MCI reported shorter sleep duration and lower overall sleep quality.

中文翻译：

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前驱阿尔茨海默病的主观睡眠参数：病例对照研究

目标 患有阿尔茨海默病 (AD) 痴呆症的人睡眠受损。然而，AD早期的睡眠特征尚不为人所知，也缺乏借助生物标志物的研究。我们评估了非痴呆老年人的主观睡眠特征，并比较了他们的淀粉样蛋白谱。方法 我们招募了 30 名年龄 ≥ 60 岁的参与者，没有痴呆或主要的临床和精神疾病。他们接受了 [11C] PiB-PET-CT、神经心理学评估，并完成了两项标准化的睡眠评估（匹兹堡睡眠质量量表和 Epworth 睡眠量表）。结果 两组主观睡眠参数的比较分析显示，淀粉样蛋白阳性个体的卧床时间更长 (p = 0.024) 和睡眠效率降低 (p = 0.05)。没有观察到其他主观睡眠参数的差异。我们还发现，与单域 MCI 患者相比，多域轻度认知障碍 (MCI) 患者自我报告的总睡眠时间更短 (p = 0.034)，整体睡眠质量更差 (p = 0.027)。结论 无论认知状态如何，淀粉样蛋白检测呈阳性的老年人在床上的时间更长，睡眠效率更低。同时，多域 MCI 的个体报告睡眠持续时间较短，整体睡眠质量较低。结论 无论认知状态如何，淀粉样蛋白检测呈阳性的老年人在床上的时间更长，睡眠效率更低。同时，多域 MCI 的个体报告睡眠持续时间较短，整体睡眠质量较低。结论 无论认知状态如何，淀粉样蛋白检测呈阳性的老年人在床上的时间更长，睡眠效率更低。与此同时，多域 MCI 的个体报告睡眠时间较短，整体睡眠质量较低。