Intraplaque hemorrhage (IPH), which is a trigger and conveys all blood components into the plaque, influencing the cholesterol crystal formation and retention, haemoglobin and oxidative enzymes, and blood-borne proteolytic activity. IPH is one of the key determinants for plaque vulnerability. In this paper, we proposed a dual-modality endoscope probe with a diameter of 1 mm for simultaneously detecting the lipid core and IPH, our system was composed of photoacoustic imaging (PAI) and near-infrared auto-fluorescence imaging (NIRAFI). The lipid as endogenous marker of intravascular PAI could visualize the lipid distribution of atherosclerotic plaque, and bilirubin as the marker of intravascular NIRAFI was used to locate and quantify the IPH. The phantom and ex vivo rabbit aorta experiments had proved the feasibility and capability of the dual-mode probe for imaging IPH and lipid core expansion. And the results indicated that the dual-mode intravascular endoscope had the potential for accurately detecting IPH in atherosclerotic plaques.

中文翻译：

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血管内光声和自体荧光成像检测斑块内出血：可行性研究

斑块内出血 (IPH)，它是触发因素并将所有血液成分输送到斑块中，影响胆固醇晶体的形成和保留、血红蛋白和氧化酶以及血液中的蛋白水解活性。IPH 是斑块易损性的关键决定因素之一。在本文中，我们提出了一种直径为 1 mm 的双模态内窥镜探头，用于同时检测脂质核心和 IPH，我们的系统由光声成像 (PAI) 和近红外自发荧光成像 (NIRAFI) 组成。脂质作为血管内PAI的内源性标志物可以可视化动脉粥样硬化斑块的脂质分布，胆红素作为血管内NIRAFI的标志物用于定位和量化IPH。体模和离体兔主动脉实验证明了双模式探针成像 IPH 和脂质核心扩张的可行性和能力。结果表明，双模式血管内窥镜具有准确检测动脉粥样硬化斑块中 IPH 的潜力。