Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has been declared a pandemic by WHO. The clinical manifestation and disease progression in COVID-19 patients varies from minimal symptoms to severe respiratory issues with multiple organ failure. Understanding the mechanism of SARS-CoV-2 interaction with host cells will provide key insights into the effective molecular targets for the development of novel therapeutics. Recent studies have identified virus-mediated phosphorylation or activation of some major signaling pathways, such as ERK1/2, JNK, p38, PI3K/AKT and NF-κB signaling, that potentially elicit the cytokine storm that serves as a major cause of tissue injuries. Several studies highlight the aggressive inflammatory response particularly ‘cytokine storm’ in SARS-CoV-2 patients. A depiction of host molecular dynamics triggered by SARS-CoV-2 in the form of a network of signaling molecules will be helpful for COVID-19 research. Therefore, we developed the signaling pathway map of SARS-CoV-2 infection using data mined from the recently published literature. This integrated signaling pathway map of SARS-CoV-2 consists of 326 proteins and 73 reactions. These include information pertaining to 1,629 molecular association events, 30 enzyme catalysis events, 43 activation/inhibition events, and 8,531 gene regulation events. The pathway map is publicly available through WikiPathways: https://www.wikipathways.org/index.php/Pathway:WP5115.

冠状病毒病 (COVID-19) 是由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的。世界卫生组织已宣布 COVID-19 为大流行病。COVID-19 患者的临床表现和疾病进展各不相同，从最轻微的症状到伴有多器官衰竭的严重呼吸系统问题。了解 SARS-CoV-2 与宿主细胞相互作用的机制将为开发新型疗法的有效分子靶点提供重要见解。最近的研究发现病毒介导的磷酸化或一些主要信号传导途径的激活，例如 ERK1/2、JNK、p38、PI3K/AKT 和 NF-κB 信号传导，可能引发细胞因子风暴，这是组织损伤的主要原因。几项研究强调了 SARS-CoV-2 患者的侵袭性炎症反应，尤其是“细胞因子风暴”。以信号分子网络的形式描述 SARS-CoV-2 触发的宿主分子动力学将有助于 COVID-19 研究。因此，我们利用从最近发表的文献中挖掘的数据开发了 SARS-CoV-2 感染的信号通路图。这张 SARS-CoV-2 的整合信号通路图由 326 个蛋白质和 73 个反应组成。其中包括与 1,629 个分子关联事件、30 个酶催化事件、43 个激活/抑制事件和 8,531 个基因调控事件有关的信息。路径图可通过 WikiPathways 公开获取：https://www.wikipathways.org/index.php/Pathway:WP5115。