Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention. Mitsugumin 53 (MG53), also known as TRIM72, is a TRIM family protein that was found to be involved in cell membrane repair and primarily found in striated muscle. Its role in skeletal muscle regeneration and myogenesis has been well documented. However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. This review summarizes the regulatory role of MG53 in cardiac tissues, current debates regarding MG53 in diabetes and diabetic cardiomyopathy, as well as highlights potential clinical applications of MG53 in treating cardiac pathologies.

中文翻译：

---

MG53的心脏作用及临床应用


心脏病仍然是全球死亡的主要原因，因此需要进一步研究以确定其潜在机制以及治疗和预防的潜在目标。 Mitsugumin 53 (MG53)，也称为 TRIM72，是一种 TRIM 家族蛋白，被发现参与细胞膜修复，主要存在于横纹肌中。它在骨骼肌再生和肌生成中的作用已得到充分证明。然而，越来越多的证据表明，MG53 对心脏组织具有潜在的保护作用，包括心脏缺血/再灌注损伤、心肌细胞膜损伤修复和心房纤维化。本综述总结了 MG53 在心脏组织中的调节作用、当前关于 MG53 在糖尿病和糖尿病心肌病中的争论，并强调了 MG53 在治疗心脏病方面的潜在临床应用。