Recent advances in high-resolution structural studies of protein amyloids have revealed parallel in-register cross-β-sheets with periodic arrays of closely spaced identical residues. What do these structures tell us about the mechanisms of action of common amyloid-promoting factors, such as heparan sulfate (HS), nucleic acids, polyphosphates, anionic phospholipids, and acidic pH?

中文翻译：

---

蛋白质淀粉样蛋白辅因子：带电侧链阵列符合他们的要求吗？

蛋白质淀粉样蛋白高分辨率结构研究的最新进展揭示了平行的登记交叉β-折叠，具有紧密间隔的相同残基的周期性阵列。这些结构告诉我们常见的淀粉样蛋白促进因子（如硫酸乙酰肝素 (HS)、核酸、多磷酸盐、阴离子磷脂和酸性 pH 值）的作用机制是什么？