Quantum Dots: A Promising Fluorescent Label for Probing Virus Trafficking,Accounts of Chemical Research

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Quantum Dots: A Promising Fluorescent Label for Probing Virus Trafficking
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2021-06-28 , DOI: 10.1021/acs.accounts.1c00276
Zhi-Gang Wang ₁ , Shu-Lin Liu ₁ , Dai-Wen Pang ₁

Affiliation

Recent research has highlighted the immense potential of the quantum dot (QD)-based single-virus tracking (SVT) technique in virology. In these experiments, the infection behaviors of single viruses or viral components, labeled with QDs, could be tracked on time scales of milliseconds to hours in host cells. The trajectories of individual viruses are reconstructed with nanometer accuracy, and the underlying dynamic information on virus infection can be extracted to uncover the infection mechanisms of viruses. Therefore, QD-based single-virus tracking (QSVT) is an exquisitely selective and powerful approach to investigating how viruses are internalized in host cells dynamically to release their genome for viral replication and assembly that ensure the completion of viral life cycles.

中文翻译：

量子点：用于探测病毒贩运的有前途的荧光标签

最近的研究强调了基于量子点 (QD) 的单病毒追踪 (SVT) 技术在病毒学中的巨大潜力。在这些实验中，用量子点标记的单个病毒或病毒成分的感染行为可以在宿主细胞中以毫秒到数小时的时间尺度进行跟踪。以纳米精度重建单个病毒的轨迹，提取病毒感染的底层动态信息，揭示病毒的感染机制。因此，基于 QD 的单病毒追踪 (QSVT) 是一种非常有选择性和强大的方法，用于研究病毒如何动态地内化在宿主细胞中，以释放其基因组进行病毒复制和组装，从而确保病毒生命周期的完成。

更新日期：2021-07-20

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