This randomized, controlled study compared the efficacy and safety between oxycodone–paracetamol tablet and celecoxib for postoperative analgesia in patients who underwent arthroscopic knee surgery (AKS). Totally, 232 patients scheduled to undergo AKS were enrolled and were randomly assigned to either the oxycodone–paracetamol (OPT group) or the celecoxib group (CEL group). Pain at rest/motion (based on pain visual analog scale (VAS) score), rescue analgesia consumption, satisfaction level and adverse events were assessed after AKS. Pain VAS score at rest was decreased at 6 h, 12 h post-AKS in the OPT group compared with the CEL group. Similarly, pain VAS score at motion was reduced at 6 h, 12 h, 24 h post-AKS in the OPT group compared to the CEL group. Furthermore, both rescue analgesia rate (14.7% vs. 33.6%) and accumulated pethidine consumption (3.7 ± 8.9 mg vs. 14.0 ± 21.2 mg) were lower in OPT group compared with the CEL group. Patients satisfaction score was either at 24 h, 48 h in OPT group compared with the CEL group. Further subgroup analyses indicated that the effect of oxycodone–paracetamol versus (vs. celecoxib) on post-AKS management was more apparent in the elderly patients and male patients. In addition, the adverse events were well tolerable (including nausea, constipation, vomiting, drowsiness and dizziness) and were of no different between the two groups. In conclusion, oxycodone–paracetamol tablet presents increased analgesic efficacy for acute postoperative pain, with higher patient satisfaction and comparable safety profiles compared with celecoxib in patients underwent AKS.

这项随机对照研究比较了羟考酮扑热息痛片和塞来昔布对膝关节镜手术 (AKS) 患者术后镇痛的疗效和安全性。总共有 232 名计划接受 AKS 的患者被纳入，并被随机分配到羟考酮-扑热息痛组（OPT 组）或塞来昔布组（CEL 组）。在 AKS 后评估休息/运动时的疼痛（基于疼痛视觉模拟量表 (VAS) 评分）、救援镇痛剂消耗、满意度和不良事件。与 CEL 组相比，OPT 组 AKS 后 6 小时、12 小时静息时疼痛 VAS 评分降低。同样，与 CEL 组相比，OPT 组在 AKS 后 6 小时、12 小时、24 小时运动时疼痛 VAS 评分降低。此外，两种抢救镇痛率（14.7% vs .与 CEL 组相比，OPT 组的 33.6% 和累积哌替啶消耗量（3.7 ± 8.9 mg 对比14.0 ± 21.2 mg）较低。与CEL组相比，OPT组在24小时、48小时的患者满意度得分。进一步的亚组分析表明，羟考酮-扑热息痛与（与.塞来昔布）对 AKS 后管理的影响在老年患者和男性患者中更为明显。此外，不良事件耐受性良好（包括恶心、便秘、呕吐、嗜睡和头晕），两组间无差异。总之，与接受 AKS 的患者中的塞来昔布相比，羟考酮 - 扑热息痛片剂对急性术后疼痛的镇痛效果更高，患者满意度更高，安全性也相当。