A number of currently used drugs have been obtained from medicinal plants which are a major source of drugs. These drugs are either used in their pure form or modified to a semisynthetic drug. Drug discovery through natural product research has been fruitful over the years. Traditionally, Calotropis procera is used extensively in the management of epilepsy. This study is conducted to explore the anticonvulsant effect of a hydroethanolic leaf extract of Calotropis procera (CPE) in murine models. This effect was evaluated using picrotoxin-induced convulsions, strychnine-induced convulsions, and isoniazid- and pilocarpine-induced status epilepticus in mice of both sexes. The results showed that CPE (100-300 mg/kg) exhibited an anticonvulsant effect against strychnine-induced clonic seizures by significantly reducing the duration () and frequency () of convulsions. The extract (100-300 mg/kg) caused a profound dose-dependent delay in the onset of clonic convulsions induced by picrotoxin () and tonic convulsions () in mice. The duration of convulsions was reduced significantly also for both clonic and tonic () seizures as well. CPE (100-300 mg/kg), showed a profound anticonvulsant effect and reduced mortality in the pilocarpine-induced convulsions. ED₅₀ (~0.1007) determined demonstrated that the extract was less potent than diazepam in reducing the duration and onset of convulsions but had comparable efficacies. Flumazenil—a GABA_A receptor antagonist—did not reverse the onset or duration of convulsions produced by the extract in the picrotoxin-induced seizure model. In isoniazid-induced seizure, CPE (300 mg kg¹, p.o.) significantly () delayed the onset of seizure in mice and prolonged latency to death in animals. Overall, the hydroethanolic leaf extract of Calotropis procera possesses anticonvulsant properties.

中文翻译：

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Calotropis procera (Ait) R. Br. 水乙醇叶提取物的抗惊厥作用。（夹竹桃科）

许多目前使用的药物是从药用植物中获得的，药用植物是药物的主要来源。这些药物要么以其纯​​净形式使用，要么被修饰为半合成药物。多年来，通过天然产物研究发现药物取得了丰硕的成果。传统上，Calotropis procera广泛用于治疗癫痫。本研究旨在探讨牛角豆(CPE) 的水乙醇叶提取物在小鼠模型中的抗惊厥作用。使用印防己毒素诱发的抽搐、士的宁诱发的抽搐以及异烟肼和毛果芸香碱诱发的癫痫持续状态来评估这种效果在两性小鼠中。结果表明，CPE（100-300 mg/kg）通过显着缩短持续时间，对士的宁引起的阵挛性发作具有抗惊厥作用。)和频率 ()抽搐。提取物（100-300 mg/kg）在印防己毒素诱导的阵挛性惊厥发作中引起严重的剂量依赖性延迟（)和强直性抽搐 ()在老鼠身上。阵挛和强直的抽搐持续时间也显着减少（)癫痫发作。CPE (100-300 mg/kg) 在毛果芸香碱引起的惊厥中表现出深刻的抗惊厥作用并降低死亡率。ED ₅₀ (~0.1007) 测定表明，该提取物在减少惊厥的持续时间和发作方面不如地西泮有效，但具有相当的功效。氟马西尼（一种 GABA _A受体拮抗剂）在印防己毒素诱导的癫痫模型中不能逆转提取物引起的惊厥发作或持续时间。在异烟肼引起的癫痫发作中，CPE (300 mg kg ¹ , po ) 显着 ()延缓了小鼠的癫痫发作和延长了动物的死亡潜伏期。总体而言， Calotropis procera的水乙醇叶提取物具有抗惊厥特性。