Very few people are able to quit smoking, and therefore it is essential to know which factors contribute to the development of compulsive nicotine use. These studies aimed to investigate if early-adolescent nicotine exposure causes locomotor sensitization and affects anxiety-like behavior and the spontaneous acquisition of intravenous nicotine self-administration. Early-adolescent male and female rats were treated with nicotine from postnatal (P) days 24 to 42, and anxiety-like behavior and locomotor activity were investigated one day after the cessation of nicotine treatment and in adulthood (>P75). The spontaneous acquisition of nicotine self-administration was also investigated in adulthood. The rats self-administered 0.03 mg/kg/infusion of nicotine for six days under a fixed-ratio (FR) 1 schedule and four days under an FR2 schedule (3-h sessions). Repeated nicotine administration increased locomotor activity, rearing, and stereotypies in a small open field in adolescent male and female rats. One day after the last nicotine injection, the percentage of open arm entries in the elevated plus-maze test was decreased in the males and increased in the females. However, locomotor activity in the small open field was unaffected. Adolescent nicotine treatment did not affect anxiety-like behavior and locomotor activity in adulthood. During the 10-day nicotine self-administration period, the females had a higher level of nicotine intake than the males. Adolescent nicotine treatment decreased nicotine intake in the females. In conclusion, these findings indicate that repeated nicotine administration during adolescence causes robust behavioral sensitization and leads to lower nicotine intake in females throughout the acquisition period in adulthood in rats.

很少有人能够戒烟，因此有必要了解哪些因素导致了强迫性尼古丁使用的发展。这些研究旨在调查青少年早期尼古丁暴露是否会导致运动敏感并影响焦虑样行为和自发获得静脉内尼古丁自我给药。从出生后 (P) 天 24 到 42 用尼古丁治疗早期青春期雄性和雌性大鼠，并在尼古丁治疗停止后一天和成年期研究焦虑样行为和运动活动 (>P75)。在成年期也研究了尼古丁自我给药的自发获得。大鼠自行给药 0。在固定比率 (FR) 1 时间表下，03 mg/kg/输注尼古丁 6 天，在 FR2 时间表下 4 天（3 小时疗程）。在青春期雄性和雌性大鼠的小空旷场地中，反复服用尼古丁会增加运动活动、饲养和刻板印象。在最后一次尼古丁注射后一天，在高架十字迷宫测试中，男性的开放臂进入百分比降低，而女性则增加。然而，在小空地上的运动活动不受影响。青少年尼古丁治疗不影响成年期的焦虑样行为和运动活动。在 10 天的尼古丁自我给药期间，女性的尼古丁摄入量高于男性。青少年尼古丁治疗减少了女性的尼古丁摄入量。综上所述，