Fungi have been recognized as a prolific source of bioactive compounds with a wide spectrum of bioactivities, nevertheless, the information about marine polar fungi is scarce. Due to this fact, the purpose of this study was to investigate the antiproliferative activity and antioxidant capacity of the extracts of three fungal strains isolated from the White Sea (Coprinellus diseminatus, Simplicillium lamellicola and Akanthomyces muscarius). The antiproliferative activity test was carried out by the SRB method and the cell lines tested were A549, HBL-100, HeLa, SW1573, T-47D and WiDr. The antioxidant capacity was measured employing the ABTS and galvinoxyl methods. The strain that showed the most antiproliferative activity was A. muscarius; it demonstrated activity in all the extracts tested, at least against two of the six tested cell lines, also the biomass ethanolic extract and the culture broth ethyl acetate extract of Coprinellus diseminatus showed antiproliferative activity against some of the tested cell lines. In the antioxidant capacity test, the ethyl acetate extracts of the culture broth of the three strains showed more activity. This indicates that arctic marine-derived fungi are capable to produce bioactive metabolites with antiproliferative activity and antioxidant capacity, comparable to other marine-derived fungi, and in some cases even more active than known medicinal mushrooms.

真菌被认为是具有广泛生物活性的生物活性化合物的丰富来源，然而，关于海洋极地真菌的信息很少。由于这一事实，本研究的目的是研究从白海分离的三种真菌菌株（Coprinellus diseminatus、Simplicillium lamellicola和Akanthomyces muscarius）的提取物的抗增殖活性和抗氧化能力。抗增殖活性试验采用SRB法，试验细胞系为A549、HBL-100、HeLa、SW1573、T-47D和WiDr。抗氧化能力的测量采用 ABTS 和 galvinoxyl 方法。表现出最大抗增殖活性的菌株是毒蕈菌; 它在所有测试的提取物中显示出活性，至少对六种测试细胞系中的两种具有活性，并且生物质乙醇提取物和鬼伞的培养液乙酸乙酯提取物显示出对一些测试细胞系的抗增殖活性。在抗氧化能力测试中，三株菌种培养液的乙酸乙酯提取物表现出更高的活性。这表明北极海洋来源的真菌能够产生具有抗增殖活性和抗氧化能力的生物活性代谢物，与其他海洋来源的真菌相当，在某些情况下甚至比已知的药用蘑菇更活跃。