Functional imaging of microvascular dynamics in extremities delivers intuitive information for early detection, diagnosis, and prognosis of vascular diseases. High-resolution and high-speed photoacoustic microscopy (PAM) visualizes and measures multiparametric information of microvessel networks in vivo such as morphology, flow, oxygen saturation, and metabolic rate. Here, we demonstrate high-resolution photoacoustic monitoring of vascular dynamics in human fingers. We photoacoustically monitored the position displacement of blood vessels associated with arterial pulsation in human fingers. Then, during and after arterial occlusion, we photoacoustically quantified oxygen consumption and blood perfusion in the fingertips. The results demonstrate that high-resolution functional PAM could be a vital tool in peripheral vascular examination for measuring heart rate, oxygen consumption, and/or blood perfusion.

四肢微血管动力学的功能成像为血管疾病的早期检测、诊断和预后提供直观的信息。高分辨率和高速光声显微镜 (PAM) 可视化和测量体内微血管网络的多参数信息如形态、流量、氧饱和度和代谢率。在这里，我们展示了人类手指血管动力学的高分辨率光声监测。我们通过光声监测与人类手指动脉搏动相关的血管位置位移。然后，在动脉闭塞期间和之后，我们光声量化了指尖的耗氧量和血液灌注。结果表明，高分辨率功能性 PAM 可能是测量心率、耗氧量和/或血液灌注的外周血管检查的重要工具。