Introduction

The left ventricular systolic longitudinal function, traditionally measured by M-mode–derived mitral annular plane systolic excursion (MAPSE), is reduced in feline hypertrophic cardiomyopathy (HCM) and further reduced in cats with left-sided congestive heart failure (CHF). The objectives of this study were to compare longitudinal displacement measured by tissue tracking (TT-LD) and MAPSE in feline HCM and assess these methods’ ability to differentiate CHF from preclinical HCM. A further objective was to provide preliminary reference intervals for TT-LD.

Animals

Eighty-five client-owned cats.

Methods

A retrospective case–control study. Anatomical M-mode was used to record MAPSE, and TT-LD was recorded by tissue tracking.

Results

Reduced longitudinal displacement measured by either MAPSE or TT-LD was significantly associated with CHF in cats with HCM (p < 0.036). Receiver-operating characteristic analysis indicated that TT-LD (AUC: 92.9%–97.9%) was more sensitive and specific than MAPSE (AUC: 85.8%–89.1%) for the detection of CHF. A diagnostic cut-off of 2.89 mm for maximal TT-LD in the left ventricular septum resulted in a sensitivity and specificity of 100% and 83.3%, while a diagnostic cut-off of 2.41 mm in the left ventricular posterior wall resulted in a sensitivity of 100% and a specificity of 90%.

Conclusions

M-mode–derived mitral annular plane systolic excursion and TT-LD were strongly correlated, but not interchangeable. Longitudinal displacement measured by tissue tracking decreased more with disease severity than traditional MAPSE. Longitudinal displacement may help detect CHF in cats with HCM – with the maximal TT-LD of the left ventricular posterior wall achieving the highest AUC value.

中文翻译：

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肥厚型心肌病猫通过二尖瓣环位移检测充血性心力衰竭——组织多普勒成像衍生的组织追踪与 M 型之间的一致性

介绍

左心室收缩纵向功能，传统上通过 M 模式衍生的二尖瓣环平面收缩偏移 (MAPSE) 测量，在猫肥厚性心肌病 (HCM) 中降低，在患有左侧充血性心力衰竭 (CHF) 的猫中进一步降低。本研究的目的是比较通过组织追踪 (TT-LD) 和 MAPSE 在猫 HCM 中测量的纵向位移，并评估这些方法区分 CHF 与临床前 HCM 的能力。另一个目标是为 TT-LD 提供初步参考区间。

动物

八十五只客户拥有的猫。

方法

回顾性病例对照研究。解剖M-mode用于记录MAPSE，TT-LD通过组织追踪记录。

结果

通过 MAPSE 或 TT-LD 测量的纵向位移减少与患有 HCM 的猫的 CHF 显着相关（p  < 0.036）。接受者操作特征分析表明，在检测 CHF 方面，TT-LD（AUC：92.9%–97.9%）比 MAPSE（AUC：85.8%–89.1%）更敏感和特异。左室间隔最大 TT-LD 的诊断临界值 2.89 mm 的敏感性和特异性分别为 100% 和 83.3%，而左心室后壁的诊断临界值 2.41 mm 导致敏感性和特异性100% 和 90% 的特异性。

结论

M 型衍生的二尖瓣环平面收缩期偏移与 TT-LD 密切相关，但不可互换。与传统的 MAPSE 相比，通过组织追踪测量的纵向位移随疾病严重程度的降低更多。纵向位移可能有助于检测患有 HCM 的猫的 CHF——左心室后壁的最大 TT-LD 达到最高的 AUC 值。