Introduction: Chronic loneliness has been linked to many adverse outcomes, including mental health problems. Psychological treatment of loneliness can be effective, but the evidence base is limited. Objective: To investigate the efficacy of 2 internet-based interventions based on cognitive behavioral therapy (ICBT) and interpersonal psychotherapy (IIPT) relative to a wait-list control group and each other. Methods: A total of 170 participants were recruited and randomized to either 9 weeks of ICBT (n = 68), IIPT (n = 68), or a wait-list condition (n = 34). The primary outcome was loneliness, measured using the UCLA Loneliness Scale before, during, and after treatment. Secondary measures of psychiatric disorders and quality of life were administered before and after treatment. Follow-up was conducted 4 months after the treatment had ended. Primary outcome data were analyzed using growth curve modeling. Secondary outcomes were analyzed using robust regression models. The trial was preregistered (ClinicalTrials.gov ID: NCT03807154). Results: The ICBT condition had a significantly greater impact on loneliness compared to the wait-list and IIPT conditions. Effect sizes were moderate to large (Cohen d = 0.71) compared to the wait-list and moderate (d = 0.53) compared to IIPT. The IIPT condition did not differ significantly from the wait-list. Both active treatments led to significant increases in quality of life. Only the ICBT group had significantly lower symptoms of depression and generalized anxiety compared to the wait-list group. Treatment gains were maintained but not improved at follow-up. Conclusions: ICBT can be an efficacious option for alleviating loneliness. The IIPT intervention was not as effective.
Psychother Psychosom

中文翻译：

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治疗师指导的基于互联网的孤独治疗：一项比较认知行为治疗和人际关系心理治疗的随机对照三臂试验

简介：慢性孤独与许多不良后果有关，包括心理健康问题。孤独的心理治疗可能是有效的，但证据基础有限。目的：研究基于认知行为疗法 (ICBT) 和人际心理疗法 (IIPT) 的 2 种基于互联网的干预措施相对于等待名单对照组和彼此之间的疗效。方法：共招募了 170 名参与者，并随机分配到 9 周的 ICBT（ n = 68）、IIPT（ n = 68）或等待名单条件（ n= 34)。主要结果是孤独感，使用加州大学洛杉矶分校孤独感量表在治疗前、治疗期间和治疗后进行测量。在治疗前后进行精神疾病和生活质量的次要测量。治疗结束后4个月进行随访。使用生长曲线模型分析主要结果数据。次要结果使用稳健的回归模型进行分析。该试验已预先注册（ClinicalTrials.gov ID：NCT03807154）。结果：与等待名单和 IIPT 条件相比，ICBT 条件对孤独感的影响显着更大。与等待名单和中等（d= 0.53) 与 IIPT 相比。IIPT 条件与候补名单没有显着差异。两种积极的治疗都显着提高了生活质量。与等待名单组相比，只有 ICBT 组的抑郁和广泛性焦虑症状显着降低。治疗效果得到维持，但在随访中没有改善。结论： ICBT 可以成为缓解孤独感的有效选择。IIPT 干预没有那么有效。
心理治疗师