Prospective Evaluation of Galactomannan and (1→3) β-d-Glucan Assays as Diagnostic Tools for Invasive Fungal Disease in Children, Adolescents, and Young Adults With Acute Myeloid Leukemia Receiving Fungal Prophylaxis,Journal of the Pediatric Infectious Diseases Society

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Prospective Evaluation of Galactomannan and (1→3) β-d-Glucan Assays as Diagnostic Tools for Invasive Fungal Disease in Children, Adolescents, and Young Adults With Acute Myeloid Leukemia Receiving Fungal Prophylaxis
Journal of the Pediatric Infectious Diseases Society ( IF 2.5 ) Pub Date : 2021-06-26 , DOI: 10.1093/jpids/piab036
Brian T Fisher ₁ , Ted Westling ₂ , Craig L K Boge ₁ , Theoklis E Zaoutis ₁ , Christopher C Dvorak ₃ , Michael Nieder ₄ , Danielle M Zerr ₅ , John R Wingard ₆ , Doojduen Villaluna ₇ , Adam J Esbenshade ₈ , Sarah Alexander ₉ , Suphansa Gunn ₁₀ , Lawrence J Wheat ₁₀ , Lillian Sung ₉

Affiliation

Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Department of Mathematics and Statistics, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
Division of Pediatric Allergy, Immunology and Bone Marrow Transplant, University of California San Francisco, San Francisco, California, USA.
Division of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, Florida, USA.
Division of Pediatric Infectious Diseases, Seattle Children's Hospital, Seattle, Washington, USA.
University of Florida College of Medicine, Gainesville, Florida, USA.
Children's Oncology Group, Monrovia, California, USA.
Division of Pediatric Hematology and Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Miravista Diagnostics, LLC, Indianapolis, Indiana, USA.

Patients receiving chemotherapy for acute myeloid leukemia (AML) are at high risk for invasive fungal disease (IFD). Diagnosis of IFD is challenging, leading to interest in fungal biomarkers. The objective was to define the utility of surveillance testing with Platelia Aspergillus galactomannan (GM) enzyme immunoassay (EIA) and Fungitell β-d-glucan (BDG) assay in children with AML receiving antifungal prophylaxis.

中文翻译：

半乳甘露聚糖和 (1→3) β-d-葡聚糖测定作为接受真菌预防的急性髓系白血病儿童、青少年和青年侵袭性真菌病诊断工具的前瞻性评估

接受急性髓系白血病 (AML) 化疗的患者患侵袭性真菌病 (IFD) 的风险很高。 IFD 的诊断具有挑战性，这引起了人们对真菌生物标志物的兴趣。目的是确定在接受抗真菌预防的 AML 儿童中使用 Platelia Aspergillus 半乳甘露聚糖 (GM) 酶免疫测定 (EIA) 和 Fungitell β- d-葡聚糖 (BDG) 测定进行监测检测的效用。

更新日期：2021-06-26

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