Advances in meticulous dural closure technique remain a great challenge for watertight dural closure in the aged society, because the cerebrospinal fluid (CSF) leakage after spinal surgery is often accompanied with the disgusting wound infection, meningitis and pseudomeningocele. Here, a tetra-poly (ethylene glycol) (PEG)-based hydrogel sealant is developed with collective advantages of facile operation, high safety, quick set time, easy injectability, favorable mechanical strength and powerful tissue adhesion for effective sutureless dural closure during the surgery procedure. Impressively, this tetra-PEG sealant can instantaneously adhere to the irregular tissue surfaces even in a liquid environment, and effectively prevent or block off the intraoperative CSF leakage for sutureless dural closure and dura regeneration. Together, this sutureless tetra-PEG adhesive can be utilized as a very promising alternative for high-efficient watertight dural closure of the clinical patients who incidentally or deliberately undergo the durotomy during the spinal surgery.

由于脊柱手术后脑脊液（CSF）渗漏常伴有令人作呕的伤口感染、脑膜炎和假性脑膜膨出，因此精细硬脑膜缝合技术的进步仍然是老年社会对硬脑膜水密缝合的巨大挑战。在这里，开发了一种基于四聚（乙二醇）（PEG）的水凝胶密封剂，具有操作简便、安全性高、凝固时间快、易于注射、良好的机械强度和强大的组织粘附力，可在手术过程中实现有效的无缝硬脑膜闭合。手术程序。令人印象深刻的是，这种四聚乙二醇封闭剂即使在液体环境中也能瞬间粘附在不规则的组织表面，有效防止或阻断术中脑脊液渗漏，实现无缝硬脑膜闭合和硬脑膜再生。一起，