We studied the association of Enthesitis related arthritis (ERA) the most common variant of juvenile idiopathic arthritis (JIA) in Asians, with HLA-G and -E polymorphisms. HLA-G (14 bp Ins/Del rs371194629, +3142 rs1063320, +3187 rs9380142) and HLA-E (rs1264457, and rs2844724) polymorphisms were analyzed in 127 patients with ERA and 381 ethnically matched healthy controls with TaqMan 5′-nuclease assay using allele-specific fluorogenic oligonucleotide probes. HLA-G and -E polymorphisms were not found to be associated with susceptibility to ERA. HLA-G +3187 (rs9380142) G allele was associated with hip arthritis (Pc = 0.04, OR = 2.22, 95%CI = 1.07–4.63) and hip deformity (Pc = 0.02, OR = 2.51, 95%CI = 1.16–5.43). HLA-B*27 was positive in 91. HLA-E rs1264457 G and rs2844724 T alleles may be associated with B*27 positivity in ERA. Among HLA-G, -E haplotypes, frequency of -InsGAAC was significantly higher in patients than healthy controls (Pc = 0.003). In conclusion, HLA-G and HLA-E haplotype -InsGAAC may be associated with susceptibility to ERA and HLA-G +3187 rs9380142 A>G polymorphism may be a poor prognostic marker for progression to hip arthritis and deformity in ERA-JIA.

我们研究了亚洲人幼年特发性关节炎 (JIA) 最常见的变体附着点炎相关性关节炎 (ERA) 与 HLA-G 和 -E 多态性的关系。使用 TaqMan 5'-核酸酶检测分析了 127 名 ERA 患者和 381 名种族匹配的健康对照者的 HLA-G（14 bp Ins/Del rs371194629、+3142 rs1063320、+3187 rs9380142）和 HLA-E（rs1264457 和 rs2844724）多态性使用等位基因特异性荧光寡核苷酸探针。未发现 HLA-G 和 -E 多态性与 ERA 易感性相关。 HLA-G +3187 (rs9380142) G 等位基因与髋关节炎 (Pc = 0.04, OR = 2.22, 95%CI = 1.07–4.63) 和髋关节畸形 (Pc = 0.02, OR = 2.51, 95%CI = 1.16–) 相关5.43）。 91 例 HLA-B*27 呈阳性。HLA-E rs1264457 G 和 rs2844724 T 等位基因可能与 ERA 中的 B*27 阳性相关。在HLA-G、-E单倍型中，患者中-InsGAAC的频率显着高于健康对照（Pc = 0.003）。总之，HLA-G 和 HLA-E 单倍型 -InsGAAC 可能与 ERA 易感性相关，而 HLA-G +3187 rs9380142 A>G 多态性可能是 ERA-JIA 进展为髋关节炎和畸形的不良预后标志物。