Encapsulation of Drug-Loaded Graphene Oxide-Based Nanocarrier into Electrospun Pullulan Nanofibers for Potential Local Chemotherapy of Breast Cancer,Macromolecular Chemistry and Physics

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Encapsulation of Drug-Loaded Graphene Oxide-Based Nanocarrier into Electrospun Pullulan Nanofibers for Potential Local Chemotherapy of Breast Cancer
Macromolecular Chemistry and Physics ( IF 2.5 ) Pub Date : 2021-06-25 , DOI: 10.1002/macp.202100096
Shadi Asgari _{1,

2} , Ali Pourjavadi ₂ , Mohsen Setayeshmehr ₃ , Anja Boisen _{1,

4} , Fatemeh Ajalloueian _{1,

4}

Affiliation

With the high rate of mortality associated with breast cancer among women, breast cancer treatment has attracted great deal of attention globally. To reduce the exposure of body organs to high cytotoxicity of the common chemotherapeutic drugs, local co-delivery of selected chemotherapeutics has emerged as a solution. In this work, an electrospun composite including a co-drug-loaded graphene oxide-based nanocarrier is fabricated for local anticancer applications. To increase dispersion and cellular uptake of graphene oxide (GO), first, the hydroxyl groups at the edges of GO are grafted by poly (epichlorohydrin) (PCH) to form GO-PCH. Then, the hydroxyl end groups of PCH are grafted (g) with hyperbranched polyglycerol (HPG) leading to formation of oxygen-rich nanocarrier (GO-PCH-g-HPG). Paclitaxel (PTX) and curcumin (Cur) are loaded into the GO-PCH-g-HPG nanocarrier, and are encapsulated into pullulan nanofibers using electrospinning. SEM, FTIR, and UV–Vis characterizations confirmed the presence and distribution of the nanocarrier inside the nanofibers. The drugs showed a sustained release (93 h) from the nanocarrier-loaded nanofibers in the neutral pH (7.4). According to MTT assay and optical microscopy, a synergistic cytotoxicity effect of PTX and Cur is observed. The nanocarrier-encapsulated nanofiber system represents a novel tunable drug delivery system for local chemotherapeutic applications.

中文翻译：

将载药氧化石墨烯纳米载体封装到电纺普鲁兰多糖纳米纤维中，用于乳腺癌的潜在局部化疗

由于女性乳腺癌相关死亡率很高，乳腺癌治疗在全球引起了广泛关注。为了减少身体器官对常见化疗药物的高细胞毒性的暴露，局部联合递送选定的化疗药物已成为一种解决方案。在这项工作中，制造了一种包含共载药物氧化石墨烯纳米载体的电纺复合材料，用于局部抗癌应用。为了增加氧化石墨烯（GO）的分散和细胞吸收，首先，GO边缘的羟基被聚（表氯醇）（PCH）接枝形成GO-PCH。然后，PCH 的羟基端基与超支化聚甘油 (HPG) 接枝 (g)，导致形成富氧纳米载体 (GO-PCH-g-HPG)。紫杉醇 (PTX) 和姜黄素 (Cur) 加载到 GO-PCH-g-HPG 纳米载体中，并使用静电纺丝封装到支链淀粉纳米纤维中。SEM、FTIR 和 UV-Vis 表征证实了纳米纤维内部纳米载体的存在和分布。这些药物在中性 pH 值 (7.4) 中从纳米载体纳米纤维中持续释放 (93 小时)。根据 MTT 测定和光学显微镜，观察到 PTX 和 Cur 的协同细胞毒性作用。纳米载体封装的纳米纤维系统代表了一种用于局部化学治疗应用的新型可调药物递送系统。这些药物在中性 pH 值 (7.4) 中从纳米载体纳米纤维中持续释放 (93 小时)。根据 MTT 测定和光学显微镜，观察到 PTX 和 Cur 的协同细胞毒性作用。纳米载体封装的纳米纤维系统代表了一种用于局部化学治疗应用的新型可调药物递送系统。这些药物在中性 pH 值 (7.4) 下从纳米载体纳米纤维中持续释放 (93 小时)。根据 MTT 测定和光学显微镜，观察到 PTX 和 Cur 的协同细胞毒性作用。纳米载体封装的纳米纤维系统代表了一种用于局部化学治疗应用的新型可调药物递送系统。

更新日期：2021-08-07

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