ABSTRACT

Sulforaphene (SRP) is the main isothiocyanate produced by myrosinase hydrolysis of glucoraphanin from Cruciferae plants. This review discusses the latest results on the formation, content, and stability of SRP. SRP is unstable when the solution system contains amino-acids or solvents with hydroxyl groups. Different strategies to inhibit the SRP degradation and increase the hydrolysis yield have been discussed in detail. The separation, purification and SRP determination methods are described in the review. SRP has herbicidal, antimicrobial, antimutagenic, and metabolic activities, and especially an anticancer activity. These findings indicate that SRP can be considered as a prospective therapeutic agent for major human diseases. However, for possible medicinal SRP applications, there is an urgent demand for development of new strategies for purification methods and chemical synthesis maintaining SRP stability. In addition the precise mechanism of action of SRP should be thoroughly clarified.

摘要

萝卜硫素 (SRP) 是黑芥子酶水解十字花科中的萝卜硫素产生的主要异硫氰酸酯。植物。这篇综述讨论了关于 SRP 的形成、内容和稳定性的最新结果。当溶液系统含有氨基酸或带有羟基的溶剂时，SRP 不稳定。已经详细讨论了抑制 SRP 降解和提高水解产率的不同策略。综述中描述了分离、纯化和 SRP 测定方法。SRP具有除草、抗微生物、抗诱变和代谢活性，尤其是抗癌活性。这些发现表明，SRP 可被视为主要人类疾病的潜在治疗剂。然而，对于可能的药用 SRP 应用，迫切需要开发新的纯化方法和化学合成策略以保持 SRP 稳定性。