MHC class I (MHC-I) molecules undergo an intricate folding process in order to pick up antigenic peptide to present to the immune system. In recent years, the discovery of a new peptide editor for MHC-I has added an extra level of complexity in our understanding of how peptide presentation is regulated. On top of this, the incredible diversity in MHC-I molecules leads to significant variation in the interaction between MHC-I and components of the antigen processing and presentation pathway. Here, we review our current understanding regarding how polymorphisms in human leukocyte antigen class I molecules influence their interactions with key components of the antigen processing and presentation pathway. A deeper understanding of this may offer new insights regarding how apparently subtle variation in MHC-I can have a significant impact on susceptibility to disease.

中文翻译：

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MHC I 类分子的多态性影响它们与抗原加工和呈递途径组分的相互作用

MHC I 类 (MHC-I) 分子经历了复​​杂的折叠过程，以获取抗原肽以呈递给免疫系统。近年来，MHC-I 新肽编辑器的发现为我们对肽呈递如何调控的理解增加了额外的复杂性。最重要的是，MHC-I 分子令人难以置信的多样性导致 MHC-I 与抗原加工和呈递途径组分之间的相互作用发生显着变化。在这里，我们回顾了我们目前对人类白细胞抗原 I 类分子的多态性如何影响它们与抗原加工和呈递途径的关键成分的相互作用的理解。