The prospect of using the antioxidant dipeptide carnosine for the treatment of urate nephrolithiasis was evaluated. Urate nephrolithiasis was modeled in rats by intragastric administration of a mixture of oxonic and uric acids. Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg. In rats treated with carnosine, the concentration of TBA-reactive products decreased by 1.4 times, the total antioxidant activity increased by 1.4 times, and catalase activity increased by 1.3 times. By the end of the experiment, the lactate dehydrogenate level in experimental rats was 2-fold lower than in the control, and the number of urate deposits decreased by 1.6 times with a concomitant alleviation of the inflammatory processes. Thus, the use of direct peptide antioxidant carnosine attenuated the manifestations of urate nephrolithiasis.

评价了使用抗氧化二肽肌肽治疗尿酸盐肾结石的前景。通过胃内施用含氧酸和尿酸的混合物在大鼠中模拟尿酸盐肾结石。肌肽通过管以 15 mg/kg 的剂量进行胃内给药。在用肌肽处理的大鼠中，TBA反应产物的浓度降低了1.4倍，总抗氧化活性提高了1.4倍，过氧化氢酶活性提高了1.3倍。到实验结束时，实验大鼠的乳酸脱氢水平比对照组低 2 倍，尿酸盐沉积物的数量减少了 1.6 倍，同时炎症过程也得到了缓解。因此，使用直接肽抗氧化剂肌肽减轻了尿酸盐肾结石的表现。