The presence of mutations in the gene encoding isocitrate dehydrogenase (IDH1), parameters of pro- and antioxidant activity in glioma tumor tissue, and their correlation were studied using bioinformatic analysis using STRING, IntAct, BioGrid, UniProt, SwissProt databases. The rate of detection of IDH1 gene mutations varied in different degree of anaplasia, being maximum in grade III gliomas. The intensity of free radical oxidation and activities of superoxide dismutase and catalase in the tumor tissue were significantly higher than in the control. The dependence of these parameters on the degree of anaplasia was shown. Mutations in IDH1 are associated with a decrease in antioxidant activity in the tissues of gliomas, which is critically important for the initial diagnosis, the choice of treatment options, and prediction of patient survival.

使用 STRING、IntAct、BioGrid、UniProt、SwissProt 数据库的生物信息学分析研究了编码异柠檬酸脱氢酶 ( IDH1 ) 的基因突变的存在、胶质瘤组织中的促和抗氧化活性参数及其相关性。IDH1基因突变的检出率在不同程度的间变性不同，在III级胶质瘤中最高。肿瘤组织中自由基氧化的强度和超氧化物歧化酶和过氧化氢酶的活性显着高于对照组。显示了这些参数对间变性程度的依赖性。IDH1中的突变与胶质瘤组织中抗氧化活性的降低有关，这对于初步诊断、治疗方案的选择和患者生存的预测至关重要。