We studied functional changes in rat pituitary—thyroid axis after a short-term shift in deuterium body content. Male Wistar rats consumed deuterium-enriched (500,000 ppm) or deuterium-depleted water (10 ppm) for 24 h. Rats of both experimental groups demonstrated elevated concentration of bound with transport proteins thyroxine and reduced level of thyroid-stimulating hormone in serum. No changes in the rate of thyroxine conversion to triiodothyronine were found. Thus, both the increase and reduction of deuterium body content produced similar changes in the function of the pituitary—thyroid axis with primary affection of the thyroid gland, indicative of its higher sensitivity to shift in deuterium levels.

我们研究了氘体含量短期变化后大鼠垂体-甲状腺轴的功能变化。雄性 Wistar 大鼠在 24 小时内饮用富含氘 (500,000 ppm) 或贫氘水 (10 ppm) 的水。两个实验组的大鼠均表现出与转运蛋白结合的甲状腺素浓度升高和血清中促甲状腺激素水平降低。未发现甲状腺素转化为三碘甲状腺原氨酸的速率发生变化。因此，氘体含量的增加和减少都会对垂体-甲状腺轴的功能产生相似的变化，主要影响甲状腺，表明其对氘水平变化的敏感性更高。