Restenosis remains the main complication after percutaneous coronary interventions in patients with coronary heart disease. The causes of its development include, in particular, genetic factors. We studied polymorphic loci of genes encoding endothelin-1 (EDN1 rs5370), endothelin-1 receptor (EDNRA rs5333), endothelin-converting enzyme (ECE1 rs1076669), and endothelial NO synthase (eNOS rs1549758, eNOS rs1799983, and eNOS rs2070244) in the context of in-stent restenosis development. It was found that the analyzed polymorphisms of the endothelin system genes were more significant for patients aged ≥ 65 years, while the polymorphic loci of the endothelial NO synthase gene (eNOS rs1799983 and eNOS rs1549758) were predominantly associated with time of in-stent restenosis. The obtained results can be useful for comprehensive assessment of the restenosis risk factors and the choice of optimal treatment for patients with coronary heart disease before elective surgical intervention.

再狭窄仍然是冠心病患者经皮冠状动脉介入治疗后的主要并发症。其发展的原因尤其包括遗传因素。我们研究了编码内皮素-1 ( EDN1 rs5370 )、内皮素-1受体( EDNRA rs5333 )、内皮素转换酶( ECE1 rs1076669 )和内皮一氧化氮合酶( eNOS rs1549758、eNOS rs1799983和eNOS rs2070244 )的基因的多态性位点。支架内再狭窄发展的背景。发现分析的内皮素系统基因多态性在≥65岁的患者中更为显着，而内皮NO合酶基因的多态性位点（eNOS rs1799983和eNOS rs1549758）主要与支架内再狭窄时间相关。所得结果可用于对冠心病患者择期手术干预前再狭窄危险因素的综合评估和最佳治疗方案的选择。