The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease. The level of IgG antibodies to Nprotein remained low throughout the observation period. The characteristic dynamics of IgG measured using test systems with sorbed whole virion or recombinant spike proteins reflects the duration of the disease.

使用俄罗斯测试系统通过 ELISA 确定 76 名确诊感染 COVID-19 患者的静脉血中是否存在 IgG 和 IgM 抗体。揭示了针对 N 蛋白和 Spike 蛋白 (RBD) 受体结合域的不同水平的 IgM 抗体。针对全病毒体抗原和重组抗原的 IgG 抗体的动力学在疾病的第 4-5 周显示出高值。在整个观察期间，Nprotein 的 IgG 抗体水平保持低水平。使用具有吸附的完整病毒粒子或重组刺突蛋白的测试系统测量的 IgG 的特征动态反映了疾病的持续时间。