Changes in pulmonary microcirculation were studied in isolated perfused rabbit lungs during modelling pulmonary thromboembolism under conditions of acetylcholine infusion against the background of treatment with M1 acetylcholine receptor blocker pirenzepine or blockade of muscarinic acetylcholine receptors with atropine. In the first case, the increase in pulmonary artery pressure was less pronounced than in case of atropine treatment. In response to pulmonary embolism after acetylcholine infusion against the background of pirenzepine pretreatment, the capillary hydrostatic pressure and postcapillary resistance did not change, while after atropine treatment, these parameters increased. In case of pulmonary embolism after acetylcholine infusion combined with selective blockade of M1 muscarinic acetylcholine receptors, the capillary filtration coefficient increased to a greater extent, than in the control and after blockade of muscarinic acetylcholine receptors.

在用 M1 乙酰胆碱受体阻滞剂哌仑西平治疗或用阿托品阻断毒蕈碱乙酰胆碱受体的背景下，在乙酰胆碱输注条件下模拟肺血栓栓塞时，在离体灌注兔肺中研究了肺微循环的变化。在第一种情况下，肺动脉压的增加不如阿托品治疗的情况那么明显。在哌仑西平预处理背景下，乙酰胆碱输注后肺栓塞的毛细血管静水压和毛细血管后阻力没有改变，而在阿托品治疗后，这些参数增加。在乙酰胆碱输注联合选择性阻断 M1 毒蕈碱乙酰胆碱受体后发生肺栓塞，