Pseudomonas aeruginosa, an opportunistic human pathogen, is a major health concern as it grows as a biofilm and evades the host’s immune defenses. Formation of biofilms on catheter and endotracheal tubes demands the development of biofilm-preventive (anti-biofilm) approaches and evaluation of nanomaterials as alternatives to antibiotics. The present study reports the successful biosynthesis of tellurium nanorods using cell lysate of Haloferax alexandrinus GUSF-1 (KF796625). The black particulate matter had absorption bands at 0.5 and 3.6 keV suggestive of elemental tellurium; showed x-ray diffraction peaks at 2θ values 24.50°, 28.74°, 38.99°, 43.13°, 50.23° and displayed a crystallite size of 36.99 nm. The black nanorods of tellurium were an average size of 40 nm × 7 nm, as observed in transmission electron microscopy. To our knowledge, the use of cell lysate of Haloferax alexandrinus GUSF-1 (KF796625) as a green route for the biosynthesis of tellurium nanorods with a Pseudomonas aeruginosa biofilm inhibiting capacity is novel to haloarchaea. At 50 µg mL⁻¹, these tellurium nanorods exhibited 75.03% in-vitro reduction of biofilms of Pseudomonas aeruginosa ATCC 9027, comparable to that of ciprofloxacin, which is used in treatment of Pseudomonas infections. Further, the observed ability of these nanoparticles to inhibit the formation of Pseudomonas biofilms is worthy of future research perusal.

铜绿假单胞菌是一种机会性人类病原体，是一个主要的健康问题，因为它作为生物膜生长并逃避宿主的免疫防御。在导管和气管导管上形成生物膜需要开发生物膜预防（抗生物膜）方法并评估纳米材料作为抗生素的替代品。本研究报告了使用Haloferax alexandrinus的细胞裂解物成功地生物合成碲纳米棒GUSF-1 (KF796625)。黑色颗粒物在 0.5 和 3.6 keV 处有吸收带，表明元素碲；在 2θ 值 24.50°、28.74°、38.99°、43.13°、50.23° 处显示出 X 射线衍射峰，并显示出 36.99 nm 的微晶尺寸。如在透射电子显微镜中观察到的，碲的黑色纳米棒的平均尺寸为 40 nm × 7 nm。据我们所知，使用Haloferax alexandrinus GUSF-1 (KF796625) 的细胞裂解物作为生物合成具有铜绿假单胞菌生物膜抑制能力的碲纳米棒的绿色途径对于卤古细菌来说是新的。在 50 µg mL ^{-1时，这些碲纳米棒表现出 75.03% 的}铜绿假单胞菌生物膜体外减少ATCC 9027，与用于治疗假单胞菌感染的环丙沙星相当。此外，观察到的这些纳米颗粒抑制假单胞菌生物膜形成的能力值得未来研究细读。