Alpha-amylase as molecular target for treatment of diabetes mellitus: A comprehensive review,Chemical Biology & Drug Design

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Alpha-amylase as molecular target for treatment of diabetes mellitus: A comprehensive review
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2021-06-25 , DOI: 10.1111/cbdd.13909
Navjot Kaur ₁ , Vanktesh Kumar ₁ , Surendra Kumar Nayak ₁ , Pankaj Wadhwa ₁ , Paranjit Kaur ₁ , Sanjeev Kumar Sahu ₁

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The alpha (α)-amylase is a calcium metalloenzyme that aids digestion by breaking down polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the enzyme causes postprandial hyperglycaemia and blood glucose levels to rise. α-Amylase is a well-known therapeutic target for the treatment and maintenance of postprandial blood glucose elevations. Various enzymatic inhibitors, such as acarbose, miglitol and voglibose, have been found to be effective in targeting this enzyme, prompting researchers to express an interest in developing potent alpha-amylase inhibitor molecules. The review mainly focused on designing different derivatives of drug molecules such as benzofuran hydrazone, indole hydrazone, spiroindolone, benzotriazoles, 1,3-diaryl-3-(arylamino) propan-1-one, oxadiazole and flavonoids along with their target–receptor interactions, IC₅₀ values and other biological activities.

中文翻译：

α-淀粉酶作为治疗糖尿病的分子靶点：综合综述

α (α)-淀粉酶是一种钙金属酶，它通过将多糖分子分解成较小的分子（如葡萄糖和麦芽糖）来帮助消化。此外，这种酶会导致餐后高血糖和血糖水平升高。α-淀粉酶是众所周知的治疗和维持餐后血糖升高的治疗靶点。已发现各种酶抑制剂，如阿卡波糖、米格列醇和伏格列波糖，可有效靶向这种酶，促使研究人员对开发有效的 α-淀粉酶抑制剂分子表示兴趣。综述主要集中在苯并呋喃腙、吲哚腙、螺吲哚酮、苯并三唑、1,3-diaryl-3-(arylamino) propan-1-one等药物分子的不同衍生物的设计上，₅₀值和其他生物活动。

更新日期：2021-06-25

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