Colorectal carcinoma (CRC) is a high incidence cancer and leading cause of cancer mortality worldwide. The advances in genomics and transcriptomics in the past decades have improved the detection and prevention of CRC in familial CRC syndromes. Nevertheless, the ultimate goal of personalized medicine for sporadic CRC is still not within reach due no less to the difficulty in integrating population disparity and clinical data to combat what essentially is a very heterogenous disease. This minireview highlights the achievement of the past decades and present possible direction in the hope of early detection and metastasis prevention for reducing CRC-associated morbidity and mortality.

结直肠癌 (CRC) 是一种高发癌症，也是全球癌症死亡的主要原因。过去几十年基因组学和转录组学的进步改善了家族性 CRC 综合征中 CRC 的检测和预防。尽管如此，由于难以整合人口差异和临床数据以对抗本质上是一种非常异质的疾病，因此针对散发性 CRC 的个性化医疗的最终目标仍然遥不可及。这篇小综述强调了过去几十年的成就和当前可能的方向，希望通过早期发现和预防转移来降低 CRC 相关的发病率和死亡率。