Oral administration is the most popular and patient-compliant route for drug delivery, though it raises great challenges due to the involvement of the gastro-intestine (GI) system and the drug bioavailability. Drug bioavailability is directly related to its ability to dissolve, transport and/or absorb through the physiological environment. A great number of drugs are characterized with low water solubility due to their hydrophobic nature, thus limiting their oral bioavailability and clinical use. Therefore, new strategies aiming to provide a protective shell through the GI system and improve drug solubility and permeability in the intestine were developed to overcome this limitation. Lipid-based systems have been proposed as good candidates for such a task owing to their hydrophobic nature which allows high drug loading, drug micellization ability during intestinal digestion due to the lipid content, and the vehicle physical protective environment. The use of edible lipids with high biocompatibility paves the bench-to-bedside translation. Four main types of structured lipid-based drug delivery systems differing in the physical state of the lipid phase have been described in the literature, namely emulsions, solid lipid nanoparticles, nanostructured lipid carriers, and oleogel-based particles. The current review provides a comprehensive overview of the different structured edible lipid-based oral delivery systems investigated up to date and emphasizes the contribution of each system component to the delivery performance, and the oral delivery path of lipids.

口服给药是最流行和患者顺从的给药途径，尽管由于涉及胃肠（GI）系统和药物生物利用度，它提出了巨大的挑战。药物生物利用度与其通过生理环境溶解、运输和/或吸收的能力直接相关。许多药物由于其疏水性而具有低水溶性的特点，从而限制了它们的口服生物利用度和临床应用。因此，开发了旨在通过 GI 系统提供保护壳并提高药物在肠道中的溶解度和渗透性的新策略来克服这一限制。基于脂质的系统已被提议作为此类任务的良好候选者，因为它们的疏水性允许高载药量，由于脂质含量和载体物理保护环境，药物在肠道消化过程中的胶束化能力。使用具有高生物相容性的可食用脂质为实验室到床边的转化铺平了道路。文献中描述了四种主要类型的结构化脂质药物递送系统，它们在脂质相的物理状态上有所不同，即乳液、固体脂质纳米颗粒、纳米结构化脂质载体和基于油凝胶的颗粒。本综述全面概述了迄今为止研究的不同结构化食用脂质口服递送系统，并强调了每个系统组件对递送性能的贡献，以及脂质的口服递送路径。使用具有高生物相容性的可食用脂质为实验室到床边的转化铺平了道路。文献中描述了四种主要类型的结构化脂质药物递送系统，它们在脂质相的物理状态上有所不同，即乳液、固体脂质纳米颗粒、纳米结构化脂质载体和基于油凝胶的颗粒。本综述全面概述了迄今为止研究的不同结构化食用脂质口服递送系统，并强调了每个系统组件对递送性能的贡献，以及脂质的口服递送路径。使用具有高生物相容性的可食用脂质为实验室到床边的转化铺平了道路。文献中描述了四种主要类型的结构化脂质药物递送系统，它们在脂质相的物理状态上有所不同，即乳液、固体脂质纳米颗粒、纳米结构化脂质载体和基于油凝胶的颗粒。本综述全面概述了迄今为止研究的不同结构化食用脂质口服递送系统，并强调了每个系统组件对递送性能的贡献，以及脂质的口服递送路径。即乳液、固体脂质纳米颗粒、纳米结构脂质载体和基于油凝胶的颗粒。本综述全面概述了迄今为止研究的不同结构化食用脂质口服递送系统，并强调了每个系统组件对递送性能的贡献，以及脂质的口服递送路径。即乳液、固体脂质纳米颗粒、纳米结构脂质载体和基于油凝胶的颗粒。本综述全面概述了迄今为止研究的不同结构化食用脂质口服递送系统，并强调了每个系统组件对递送性能的贡献，以及脂质的口服递送路径。