Homologous recombination (HR) plays a critical role in largely error-free repair of mitotic and meiotic DNA double-strand breaks (DSBs). DSBs are one of the most deleterious DNA lesions, which are repaired by non-homologous end joining (NHEJ), homologous recombination (HR) or, if compromised, micro-homology mediated end joining (MMEJ). If left unrepaired, DSBs can lead to cell death or if repaired incorrectly can result in chromosome rearrangements that drive cancer development. Here, we describe recent advances in the field of mitotic HR made using Caenorhabditis elegans roundworm, as a model system.

中文翻译：

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有丝分裂重组的机制：来自线虫的见解

同源重组 (HR) 在有丝分裂和减数分裂 DNA 双链断裂 (DSB) 的基本无错误修复中起着关键作用。DSB 是最有害的 DNA 损伤之一，可通过非同源末端连接 (NHEJ)、同源重组 (HR) 或微同源介导末端连接 (MMEJ) 修复。如果不加以修复，DSB 会导致细胞死亡，或者如果修复不当会导致染色体重排，从而导致癌症的发展。在这里，我们描述了使用秀丽隐杆线虫蛔虫作为模型系统进行的有丝分裂 HR 领域的最新进展。